Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

Recent years have seen significant efforts in understanding and modulating the immune
response in cancer. In this context, immunosuppressive cells, including regulatory T cells …

Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Over the past decade, our understanding of cancer immunotherapy has evolved from
assessing peripheral responses in the blood to monitoring changes in the tumour …

Background & Aims Ligand binding to inhibitory receptors on immune cells, such as
programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4) …

Background & Aims CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) have a profound ability
to control immune responses. We have previously shown that the liver is a major source of …

Liver fibrosis is a chronic, highly prevalent disease that may progress to cirrhosis and
substantially increases the risk for development of hepatocellular carcinoma (HCC). Fibrotic …

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with a high worldwide
prevalence and poor prognosis. Researches are urgently needed on its molecular …