Pathogenesis of systemic sclerosis
D Pattanaik, M Brown, BC Postlethwaite… - Frontiers in …, 2015 - frontiersin.org
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …
Current concepts on the pathogenesis of systemic sclerosis
ME Truchetet, NC Brembilla, C Chizzolini - Clinical reviews in allergy & …, 2023 - Springer
From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly
understood and lacks effective therapies. We undertook quantitative analyses of T cell …
understood and lacks effective therapies. We undertook quantitative analyses of T cell …
Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis
KG MacDonald, NAJ Dawson, Q Huang… - Journal of Allergy and …, 2015 - Elsevier
Background Systemic sclerosis (SSc) is an autoimmune disorder characterized by fibrosis of
the skin and internal organs. Pathologic conversion of regulatory T (Treg) cells into …
the skin and internal organs. Pathologic conversion of regulatory T (Treg) cells into …
How pregnancy can affect autoimmune diseases progression?
MP Piccinni, L Lombardelli, F Logiodice… - Clinical and Molecular …, 2016 - Springer
Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of
different effectors mechanisms of the immune system, namely antibodies and T cells. Their …
different effectors mechanisms of the immune system, namely antibodies and T cells. Their …
Dendritic cell-mediated Th2 immunity and immune disorders
Dendritic cells (DCs) are the professional antigen-presenting cells that recognize and
present antigens to naïve T cells to induce antigen-specific adaptive immunity. Among the T …
present antigens to naïve T cells to induce antigen-specific adaptive immunity. Among the T …
Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity
Neutrophil granulocytes, or neutrophils, are the most abundant circulating leukocytes in
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …
Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement
Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen
deposition in the skin and internal organs. Several cytokines and chemokines have been …
deposition in the skin and internal organs. Several cytokines and chemokines have been …
Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease
ME Truchetet, NC Brembilla, E Montanari… - Arthritis research & …, 2011 - Springer
Introduction T cell abnormalities have been associated with the pathogenesis of systemic
sclerosis (SSc). Recently, besides T helper (Th) 17 cells, the Th22 subset has been …
sclerosis (SSc). Recently, besides T helper (Th) 17 cells, the Th22 subset has been …
Transfer of fetal cells with multilineage potential to maternal tissue
K Khosrotehrani, KL Johnson, DH Cha, RN Salomon… - Jama, 2004 - jamanetwork.com
ContextDuring pregnancy, fetal CD34+ cells enter the maternal circulation, persist for
decades, and create a state of physiologic microchimerism. Many studies have confirmed …
decades, and create a state of physiologic microchimerism. Many studies have confirmed …