Over the last decades, life expectancy has significantly increased although several chronic
diseases persist in the population, with aging as the leading risk factor. Despite …

Breast cancer patients are at a particularly high risk of cardiotoxicity from chemotherapy
having a detrimental effect on quality-of-life parameters and increasing the risk of mortality …

Noncoding RNAs (ncRNAs), which include circular RNAs (circRNAs) and microRNAs
(miRNAs), regulate the development of cardiovascular diseases (CVD). Notably, circRNAs …

Using serial analysis of myocardial gene expression employing endomyocardial biopsy
starting material in a dilated cardiomyopathy cohort, we show that mRNA expression of the …

Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-
coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs …

Heritable cardiomyopathies are a class of heart diseases caused by variations in a number
of genetic loci. Genetic variants on one allele lead to either a degraded protein, which …

Various stresses, including pressure overload and myocardial stretch, can trigger cardiac
remodeling and result in heart diseases. The disorders are associated with high risk of …

The prevalence of heart failure with preserved ejection fraction (HFpEF) is steadily
increasing. Its diagnosis remains difficult and controversial and relies mostly on non …

Diagnosis, prognosis, treatment, and development of new therapies for diseases or
syndromes depend on a reliable means of identifying phenotypes associated with distinct …

Abstract Purpose of Review Heart failure is increasing in prevalence with a lack of recently
developed therapies that produce major beneficial effects on its associated mortality …