D Aharoni, TM Hoogland - Frontiers in cellular neuroscience, 2019 - frontiersin.org
The ability to simultaneously image the spatiotemporal activity signatures from many neurons during unrestrained vertebrate behaviors has become possible through the …
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …
W Zong, R Wu, S Chen, J Wu, H Wang, Z Zhao… - Nature …, 2021 - nature.com
We have developed a miniature two-photon microscope equipped with an axial scanning mechanism and a long-working-distance miniature objective to enable multi-plane imaging …
Miniature fluorescence microscopes are a standard tool in systems biology. However, widefield miniature microscopes capture only 2D information, and modifications that enable …
Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …
A de Groot, BJG van den Boom, RM van Genderen… - Elife, 2020 - elifesciences.org
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor neural signals during unrestrained behavior and their open-source versions have made …
C Guo, GJ Blair, M Sehgal, FN Sangiuliano Jimka… - Science …, 2023 - science.org
Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger than mice remains a key endeavor of neuroscience. We present a large-field-of-view open …
One major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Meeting this challenge comprehensively …
Neural activity in the hippocampus is known to reflect how animals move through an environment,. Although navigational behaviour may show considerable stability,,–, the …