Implantable intracortical microelectrodes: reviewing the present with a focus on the future

Y Wang, X Yang, X Zhang, Y Wang… - Microsystems & …, 2023 - nature.com
Implantable intracortical microelectrodes can record a neuron's rapidly changing action
potentials (spikes). In vivo neural activity recording methods often have either high temporal …

Circuit investigations with open-source miniaturized microscopes: past, present and future

D Aharoni, TM Hoogland - Frontiers in cellular neuroscience, 2019 - frontiersin.org
The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

[HTML][HTML] Large-scale two-photon calcium imaging in freely moving mice

W Zong, HA Obenhaus, ER Skytøen, H Eneqvist… - Cell, 2022 - cell.com
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Miniature two-photon microscopy for enlarged field-of-view, multi-plane and long-term brain imaging

W Zong, R Wu, S Chen, J Wu, H Wang, Z Zhao… - Nature …, 2021 - nature.com
We have developed a miniature two-photon microscope equipped with an axial scanning
mechanism and a long-working-distance miniature objective to enable multi-plane imaging …

Miniscope3D: optimized single-shot miniature 3D fluorescence microscopy

K Yanny, N Antipa, W Liberti, S Dehaeck… - Light: Science & …, 2020 - nature.com
Miniature fluorescence microscopes are a standard tool in systems biology. However,
widefield miniature microscopes capture only 2D information, and modifications that enable …

Breakdown of spatial coding and interneuron synchronization in epileptic mice

T Shuman, D Aharoni, DJ Cai, CR Lee, S Chavlis… - Nature …, 2020 - nature.com
Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …

NINscope, a versatile miniscope for multi-region circuit investigations

A de Groot, BJG van den Boom, RM van Genderen… - Elife, 2020 - elifesciences.org
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor
neural signals during unrestrained behavior and their open-source versions have made …

Miniscope-LFOV: a large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals

C Guo, GJ Blair, M Sehgal, FN Sangiuliano Jimka… - Science …, 2023 - science.org
Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger
than mice remains a key endeavor of neuroscience. We present a large-field-of-view open …

All the light that we can see: a new era in miniaturized microscopy

D Aharoni, BS Khakh, AJ Silva, P Golshani - Nature methods, 2019 - nature.com
One major challenge in neuroscience is to uncover how defined neural circuits in the brain
encode, store, modify, and retrieve information. Meeting this challenge comprehensively …

A stable hippocampal code in freely flying bats

WA Liberti III, TA Schmid, A Forli, M Snyder… - Nature, 2022 - nature.com
Neural activity in the hippocampus is known to reflect how animals move through an
environment,. Although navigational behaviour may show considerable stability,,–, the …