A central question in cell biology is how membrane-spanning receptors transmit
extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion …

Cell motility is stimulated by extracellular stimuli and initiated by intracellular signaling
proteins that localize to sites of cell contact with the extracellular matrix termed focal …

We identified that suppressor of cytokine signaling-3 (SOCS-3) gene was aberrantly
methylated in its CpG island in three of 10 human hepatocellular carcinoma (HCC) cell lines …

Signal transducers and activators of transcription (STATs) comprise a family of several
transcription factors that are activated by a variety of cytokines, hormones and growth …

The suppressors of cytokine signalling (SOCS) box is a structural domain found at the C-
terminus of over 70 human proteins. It is usually coupled to a protein interaction module …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer in large part due to late
diagnosis and a lack of effective screening tests. In spite of recent progress in imaging …

Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of
cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of …

In response to brain injury, microglia rapidly extend processes that isolate lesion sites and
protect the brain from further injury. Here we report that microglia carrying a pathogenic …

Suppressors of cytokine signaling (SOCS) are Src homology-2-containing proteins originally
identified as negative regulators of cytokine signaling. Accumulating evidence indicates a …

Cytokine responses can be regulated by a family of proteins termed suppressors of cytokine
signaling (SOCS) which can inhibit the JAK/STAT pathway in a classical negative-feedback …