Meiotic recombination: the essence of heredity

N Hunter - Cold Spring Harbor perspectives in biology, 2015 - cshperspectives.cshlp.org
The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

Genetic causes of spermatogenic failure

A Massart, W Lissens, H Tournaye… - Asian journal of …, 2011 - pmc.ncbi.nlm.nih.gov
Approximately 10%–15% of couples are infertile, and a male factor is involved in almost half
of these cases. This observation is due in part to defects in spermatogenesis, and the …

TEX11 is mutated in infertile men with azoospermia and regulates genome‐wide recombination rates in mouse

F Yang, S Silber, NA Leu, RD Oates… - EMBO molecular …, 2015 - embopress.org
Genome‐wide recombination is essential for genome stability, evolution, and speciation.
Mouse Tex11, an X‐linked meiosis‐specific gene, promotes meiotic recombination and …

Gene polymorphisms/mutations relevant to abnormal spermatogenesis

F Nuti, C Krausz - Reproductive biomedicine online, 2008 - Elsevier
Despite the identification of an increasing number of candidate genes involved in
spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains …

Meiotic chromosome structure, the synaptonemal complex, and infertility

IR Adams, OR Davies - Annual Review of Genomics and …, 2023 - annualreviews.org
In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein
structure, the synaptonemal complex (SC), that assembles between homologous …

Mutations in genes coding for synaptonemal complex proteins and their impact on human fertility

A Geisinger, R Benavente - Cytogenetic and genome research, 2017 - karger.com
Human infertility is often classified as idiopathic in both males and females. Meiotic errors
may account for at least part of these cases. As the synaptonemal complex (SC, a meiosis …

Maternal germline factors associated with aneuploid pregnancy loss: a systematic review

U Blyth, L Craciunas, G Hudson… - Human Reproduction …, 2021 - academic.oup.com
BACKGROUND Miscarriage describes the spontaneous loss of pregnancy before the
threshold of viability; the vast majority occur before 12 weeks of gestation. Miscarriage …

Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia

MS Oud, L Ramos, MK O'Bryan, RI McLachlan… - Human …, 2017 - Wiley Online Library
Microdeletions of the Y chromosome (YCMs), Klinefelter syndrome (47, XXY), and CFTR
mutations are known genetic causes of severe male infertility, but the majority of cases …

[HTML][HTML] Melatonin promotes goat spermatogonia stem cells (SSCs) proliferation by stimulating glial cell line-derived neurotrophic factor (GDNF) production in Sertoli …

B Niu, B Li, C Wu, J Wu, Y Yan, R Shang, C Bai, G Li… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Melatonin has been reported to be an important endogenous hormone for regulating
neurogenesis, immunityand the biological clock. Recently, the effects of melatonin on neural …

Effects of pre-mating nutrition on mRNA levels of developmentally relevant genes in sheep oocytes and granulosa cells

LF Pisani, S Antonini, P Pocar, S Ferrari… - …, 2008 - rep.bioscientifica.com
The objective was to determine the effect of dietary intake on follicle and oocyte morphology
in unstimulated and superovulated ewes. Fifty-four ewes were fed grass meal at 0.5, 1.0 or …