Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Small-molecule (SM) leads in the early drug discovery pipeline are progressed primarily
based on potency against the intended target (s) and selectivity against a very narrow slice …

Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …

Natural active products (NAPs) are derived from chemical substances found in nature that
have biological activity and medicinal potential. Screening and revealing the protein targets …

Polymorphism in drugs and bioactive molecules is not uncommon, and it has remained as
one of the critical issues in drug development processes. While improving physicochemical …

Herein we report the design, synthesis, computational, and experimental evaluation of the
antimicrobial activity of fourteen new 3-amino-5-(indol-3-yl) methylene-4-oxo-2 …

Abstract Ten 2‐(4‐acetamidophenylimino)‐5‐arylidenethiazolidin‐4‐one derivatives 6a‐k
were synthesized and evaluated for their anticancer activity against MCF‐7 cell line (breast …

Leucettamine B is a natural product found in marine sponge Leucetta microraphis. Several
of analogs of its family, such as aplysinopsine and clathridine, are medicinally active …

Introduction: Drug discovery efforts across the globe are chasing new drug targets and novel
mechanisms of action. To support the identification of novel mechanisms of action …

Finding effective and selective anticancer agents is a top medical priority due to high clinical
treatment demand. However, current anticancer agents have serious side effects and …