Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …

Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the
pathological consequences of aging; however, it is unclear what drives the senescence of …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

A role of coagulation proteases in kidney disease beyond their function in normal
haemostasis and thrombosis has long been suspected, and studies performed in the past 15 …

Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is
associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and …

Dendritic cells (DCs) are indispensable for defense against pathogens but may also
contribute to immunopathology. Activation of DCs upon the sensing of pathogens by Toll-like …

The G protein-coupled receptor (GPCR) protease-activated receptor 1 (PAR1) is a
therapeutic target that was originally pursued with the aim of restricting platelet activation …