Stroke is the fifth leading cause of death in the US, with more than 100,000 deaths annually.
There are a multitude of risks associated with stroke, including aging, cardiovascular …

Diabetic kidney disease (DKD) is a devastating condition associated with increased
morbidity and premature mortality. The etiology of DKD is still largely unknown. However …

Importance Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney
outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may …

Background/Aims: Ischemia/reperfusion injury (IRI) plays a crucial role in renal
transplantation and can cause renal failure associated with pyroptosis, a pro-inflammatory …

Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple
metabolic processes (from many molecules such as proteins, nucleotides, or …

Abstract The lipopolysaccharide (LPS)–toll-like receptor-4 (TLR4) pathway plays an
important role in liver failure. Recombinant alkaline phosphatase (recAP) deactivates LPS …

Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-
inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de …

Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme bound to the plasma
membranes of numerous cells via a glycosylphosphatidylinositol (GPI) moiety. TNAP's …

Sepsis-related mortality roughly doubles when acute kidney injury (AKI) occurs and end-
stage renal disease is more common in sepsis-associated AKI survivors. So far, no licensed …

Human antigen R (HuR) is a member of the embryonic lethal abnormal vision (ELAV) family
which can bind to the A/U rich elements in 3'un-translated region of mRNA and regulate …