Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and
therapeutic vulnerabilities. A computational approach for unbiased identification of core …

In most tissues, anchorage-dependent growth and cell cycle progression are dependent on
cells engaging extracellular matrices (ECMs) via integrin–receptor adhesion complexes. In a …

Simple Summary p53 tumour suppressor gene is the most altered in cancer. Several
decades of research have established that it is of pivotal importance in prompting neoplastic …

Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised
functions in mitosis are incompletely understood. Using degron tags for rapid inducible …

As cells prepare to divide, they must ensure that enough space is available to assemble the
mitotic machinery without perturbing tissue homeostasis. To do so, cells undergo a series of …

Oocyte meiotic maturation is a vital and final process in oogenesis. Unlike somatic cells, the
oocyte needs to undergo two continuous meiotic divisions (meiosis I and meiosis II) to …

Colorectal cancer (CRC) is the most common malignancy of digestive system with significant
mortality rate. CRC patients with comparable clinical symptoms or at similar stages of the …

Mammalian oocytes are arrested at the prophase of the first meiotic division for months and
even years, depending on species. Meiotic resumption of fully grown oocytes requires …