Targeted protein degradation (TPD) is an emerging modality for research and therapeutics.
Most TPD approaches harness cellular ubiquitin-dependent proteolytic pathways …

Post-translational modifications (PTMs) are chemical modifications that can regulate the
activity and function of proteins. From an evolutionary perspective, they also represent a fast …

Diverse (sub) cellular materials are secreted by cells into the systemic circulation at different
stages of disease progression. These circulating biomarkers include whole cells, such as …

The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus
and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic …

Mass spectrometry-based phosphoproteomics is currently the leading methodology for the
study of global kinase signaling. The scientific community is continuously releasing …

Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Proteomics is an indispensable analytical technique to study the dynamic functioning of
biological systems via different proteins and their proteoforms. In recent years, bottom-up …

Post-translational modifications (PTMs) regulate various aspects of protein function,
including degradation. Mass spectrometric methods relying on pulsed metabolic labeling …

ABSTRACT α-Synuclein (α-Syn) aggregation in Lewy bodies and Lewy neurites has
emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies …

Dominant-negative mutations can help to investigate the biological mechanisms and to
understand the selective pressures for multifunctional proteins. However, most studies have …