Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity

B Vellingiri, A Suriyanarayanan, P Selvaraj… - Chemosphere, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative condition characterized by the dopamine
(DA) neuronal loss in the substantia nigra. PD impairs motor controls symptoms such as …

Redox stress and metal dys-homeostasis appear as hallmarks of early prion disease pathogenesis in mice

JG Spiers, HJC Chen, TL Barry, JM Bourgognon… - Free Radical Biology …, 2022 - Elsevier
Neurodegenerative diseases are associated with a multitude of dysfunctional cellular
pathways. One major contributory factor is a redox stress challenge during the development …

Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson's disease

S Zhao, L Zhang, W Ji, Y Shi, G Lai, H Chi… - Frontiers in …, 2022 - frontiersin.org
Background: Parkinson's disease (PD) is a neurodegenerative disease commonly seen in
the elderly. On the other hand, cuprotosis is a new copper-dependent type of cell death that …

[PDF][PDF] Cuproptosis: copper-induced regulated cell death

WJ Duan, RR He - Science China Life Sciences, 2022 - researchgate.net
Copper is an essential trace element central to cardiovascular, neuronal, and immune
functions. While copper deficiency is generally rare, chronic or long-term copper exposure …

Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model

YQ Lv, L Yuan, Y Sun, HW Dou, JH Su, ZP Hou… - Translational …, 2022 - Springer
Background Growing evidence suggests an association between Parkinson's disease (PD)
and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have …

α-Synuclein in Parkinson's disease and advances in detection

R Chen, X Gu, X Wang - Clinica chimica acta, 2022 - Elsevier
Parkinson's disease (PD) is a threatening neurodegenerative disorder that seriously affects
patients' life quality. Substantial evidence links the overexpression and abnormal …

Copper release by MOF-74 (Cu): a novel pharmacological alternative to diseases with deficiency of a vital oligoelement

J Aguila-Rosas, BA García-Martínez, C Ríos… - RSC …, 2024 - pubs.rsc.org
Copper deficiency can trigger various diseases such as Amyotrophic Lateral Sclerosis
(ALS), Parkinson's disease (PD) and even compromise the development of living beings, as …

Crossroads between copper ions and amyloid formation in Parkinson's disease

P Wittung-Stafshede - Essays in Biochemistry, 2022 - portlandpress.com
Copper (Cu) ion dys-homeostasis and α-synclein amyloid deposits are two hallmarks of
Parkinson's disease (PD). Here, I will discuss the connections between these features, with …

Potential application of heat shock proteins as therapeutic targets in Parkinson's disease

H Guo, J Yi, F Wang, T Lei, H Du - Neurochemistry International, 2023 - Elsevier
Parkinson's disease (PD) is a common chronic neurodegenerative disease, and the heat
shock proteins (HSPs) are proved to be of great value for PD. In addition, HSPs can maintain …

Modulating α-synuclein propagation and decomposition: implications in Parkinson's disease therapy

B Li, X Xiao, M Bi, Q Jiao, X Chen, C Yan, X Du… - Ageing Research …, 2024 - Elsevier
Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …