[HTML][HTML] Human carboxylesterases: a comprehensive review
D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
Recent progress in the discovery of natural inhibitors against human carboxylesterases
DD Wang, LW Zou, Q Jin, J Hou, GB Ge, L Yang - Fitoterapia, 2017 - Elsevier
Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …
Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
T Fukami, M Kariya, T Kurokawa, A Iida… - European Journal of …, 2015 - Elsevier
Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of
some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly …
some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly …
The role of intestinal carboxylesterase in the oral absorption of prodrugs
T Imai, K Ohura - Current drug metabolism, 2010 - ingentaconnect.com
The bioavailability of therapeutic agents can be improved by using prodrugs which have
better passive diffusion than the active agents. Intestinal hydrolysis is an important reaction …
better passive diffusion than the active agents. Intestinal hydrolysis is an important reaction …
Detection techniques of carboxylesterase activity: An update review
L Lan, X Ren, J Yang, D Liu, C Zhang - Bioorganic chemistry, 2020 - Elsevier
Mammalian carboxylesterases (CESs) are essential members of serine esterase hydrolase
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …
Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes
T Fukami, M Nakajima, T Maruichi… - Pharmacogenetics …, 2008 - journals.lww.com
Objective Human carboxylesterase (CES) 1A1 gene (14 exons) and CES1A3 pseudogene
(six exons) are inverted and duplicated genes in a reference sequence (NT_010498). In …
(six exons) are inverted and duplicated genes in a reference sequence (NT_010498). In …
Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans
T Yoshida, T Fukami, T Kurokawa, S Gotoh… - European Journal of …, 2018 - Elsevier
Carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes
responsible for the hydrolysis of various clinical drugs. Our recent study demonstrated that …
responsible for the hydrolysis of various clinical drugs. Our recent study demonstrated that …
Multicolor imaging of endoplasmic reticulum-located esterase as a prodrug activation enzyme
W Hakamata, S Tamura, T Hirano… - ACS medicinal chemistry …, 2014 - ACS Publications
The carboxylesterase families of enzymes are key participants in phase I drug metabolism
processes. Carboxylesterase families 1 and 2 are of particular clinical relevance. These …
processes. Carboxylesterase families 1 and 2 are of particular clinical relevance. These …
In vitro evaluation of the inhibitory potential of pharmaceutical excipients on human carboxylesterase 1A and 2
C Zhang, Y Xu, Q Zhong, X Li, P Gao, C Feng, Q Chu… - Plos one, 2014 - journals.plos.org
Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients …
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients …