Highlights•Proteins undergo spontaneous degradation during manufacturing and
storage.•Chemical modifications to proteins can influence physical stability.•Predictive tools …

The architecture of normal and diseased tissues strongly influences the development and
progression of disease as well as responsiveness and resistance to therapy. We describe a …

Immunotherapies are revolutionizing cancer treatment by boosting the natural ability of the
immune system. In addition to antibodies against traditional checkpoint molecules or their …

There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

Multiplexed tissue imaging enables precise, spatially resolved enumeration and
characterization of cell types and states in human resection specimens. A growing number …

Attractive protein–protein interactions in concentrated monoclonal antibody (mAb) solutions
may lead to the formation of clusters that increase viscosity. Here, we propose an analytical …

The effects of a subclass of monoclonal antibodies (mAbs) on protein–protein interactions,
formation of reversible oligomers (clusters), and viscosity (η) are not well understood at high …

Excipients are substances that are added to therapeutic products to improve stability,
bioavailability, and manufacturability. Undesirable protein–protein interactions (PPI) can …

Protein solution viscosity (η) as a function of temperature was measured at a series of
protein concentrations under a range of formulation conditions for two monoclonal …

Understanding protein–protein interactions in concentrated therapeutic monoclonal
antibody (mAb) solutions is desirable for improved drug discovery, processing, and …