Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19

S Ahmad, S Manzoor, S Siddiqui, N Mariappan… - Seminars in cancer …, 2022 - Elsevier
Inflammation is an essential component of several respiratory diseases, such as chronic
obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome …

Epigenetic regulation: A link between inflammation and carcinogenesis

B Vezzani, M Carinci, M Previati, S Giacovazzi… - Cancers, 2022 - mdpi.com
Simple Summary Epigenetics encompasses all the modifications that occur within cells that
are independent of gene mutations. The environment is the main influencer of these …

Epigenetic regulation of inflammatory signaling and inflammation-induced cancer

SYX Tan, J Zhang, WW Tee - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Epigenetics comprise a diverse array of reversible and dynamic modifications to the cell's
genome without implicating any DNA sequence alterations. Both the external environment …

DNA adductomics for the biological effect assessment of contaminant exposure in marine sediments

G Martella, E Gorokhova, PFM Sousa… - Environmental …, 2023 - ACS Publications
Exposure to chemical pollution can induce genetic and epigenetic alterations,
developmental changes, and reproductive disorders, leading to population declines in …

[HTML][HTML] Role of epigenetic mechanisms in the pathogenesis of chronic respiratory diseases and response to inhaled exposures: From basic concepts to clinical …

RZ Jurkowska - Pharmacology & Therapeutics, 2024 - Elsevier
Epigenetic modifications are chemical groups in our DNA (and chromatin) that determine
which genes are active and which are shut off. Importantly, they integrate environmental …

The past and future of inflammation as a target to cancer prevention

L Antonucci, M Karin - Cancer Prevention Research, 2024 - AACR
Inflammation is an essential defense mechanism in which innate immune cells are
coordinately activated on encounter of harmful stimuli, including pathogens, tissue injury …

Small airways disease, biomarkers and COPD: where are we?

PS Chukowry, DA Spittle, AM Turner - International journal of …, 2021 - Taylor & Francis
The response to treatment and progression of Chronic Obstructive Pulmonary Disease
(COPD) varies significantly. Small airways disease (SAD) is being increasingly recognized …

[HTML][HTML] A Multi-Omics Study of Epigenetic Changes in Type II Alveolar Cells of A/J Mice Exposed to Environmental Tobacco Smoke

Q Han, J Fernandez, AT Rajczewski, TJY Kono… - International journal of …, 2024 - mdpi.com
Lung cancer remains a major contributor to cancer fatalities, with cigarette smoking known to
be responsible for up to 80% of cases. Based on the ability of cigarette smoke to induce …

[HTML][HTML] Association of exposure to second-hand smoke during childhood with blood DNA methylation

M Cosin-Tomas, T Hoang, C Qi, GS Monasso… - Environment …, 2025 - Elsevier
Introduction By recent estimates, 40% of children worldwide are exposed to second-hand
smoke (SHS), which has been associated with adverse health outcomes. While numerous …

DNA hydroxymethylation in smoking-associated cancers

A Besaratinia, A Caceres, S Tommasi - International journal of molecular …, 2022 - mdpi.com
5-hydroxymethylcytosine (5-hmC) was first detected in mammalian DNA five decades ago.
However, it did not take center stage in the field of epigenetics until 2009, when ten-eleven …