[HTML][HTML] Metabolic recruitment in brain tissue
Information processing imposes urgent metabolic demands on neurons, which have
negligible energy stores and restricted access to fuel. Here, we discuss metabolic …
negligible energy stores and restricted access to fuel. Here, we discuss metabolic …
The astrocyte: metabolic hub of the brain
LF Barros, S Schirmeier… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Astrocytic metabolism has taken center stage. Interposed between the neuron and the
vasculature, astrocytes exert control over the fluxes of energy and building blocks required …
vasculature, astrocytes exert control over the fluxes of energy and building blocks required …
[HTML][HTML] Neurovascular coupling and CO2 interrogate distinct vascular regulations
Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in
response to neuronal activation, is commonly used to map brain activation or dysfunction …
response to neuronal activation, is commonly used to map brain activation or dysfunction …
Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation
The role of parvalbumin (PV) interneurons in vascular control is poorly understood. Here, we
investigated the hemodynamic responses elicited by optogenetic stimulation of PV …
investigated the hemodynamic responses elicited by optogenetic stimulation of PV …
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity
K Li, EC Gonye, RL Stornetta, CB Bayliss… - The Journal of …, 2023 - Wiley Online Library
The interoceptive homeostatic mechanism that controls breathing, blood gases and acid‐
base balance in response to changes in CO2/H+ is exquisitely sensitive, with convergent …
base balance in response to changes in CO2/H+ is exquisitely sensitive, with convergent …
[HTML][HTML] Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch
A Hariharan, CD Robertson, DCG Garcia, TA Longden - Cell reports, 2022 - cell.com
Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and
glia, little is known of the contributions of these cells to the control of brain hemodynamics …
glia, little is known of the contributions of these cells to the control of brain hemodynamics …
On the use and misuse of cerebral hemodynamics terminology using transcranial Doppler ultrasound: a call for standardization
RJ Skow, RM Brothers… - American Journal …, 2022 - journals.physiology.org
Cerebral hemodynamics, eg, cerebral blood flow, can be measured and quantified using
many different methods, with transcranial Doppler ultrasound (TCD) being one of the most …
many different methods, with transcranial Doppler ultrasound (TCD) being one of the most …
Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, p …
M DiNuzzo, GA Dienel, KL Behar… - Journal of …, 2024 - Wiley Online Library
During transient brain activation cerebral blood flow (CBF) increases substantially more than
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …
[HTML][HTML] Enlightening brain energy metabolism
Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …
compartments, which activate at different times and with different temporal patterns. The …
Circadian biology and the neurovascular unit
Mammalian physiology and cellular function are subject to significant oscillations over the
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …