In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant
properties that may be protective but can also be pro-oxidant, depending on its chemical …

A complex interplay of environmental factors impacts the metabolism of human cells, but
neither traditional culture media nor mouse plasma mimic the metabolite composition of …

Background The NOD–like receptor pyrin domain–containing protein 3 (NLRP3)
inflammasome activation–mediated pyroptosis pathway has been linked to myocardial …

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and
cardiovascular events. In this report, we review the epidemiologic evidence and potential …

An elevation in circulating serum uric acid is strongly associated with the development of
hypertension and renal disease, but whether uric acid has a causal role or whether it simply …

Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …

In addition to its role as a metabolic waste product, uric acid has been proposed to be an
important molecule with multiple functions in human physiologic and pathophysiologic …

Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase
activity by various mutations of its gene during the Miocene epoch, which led to humans …

Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in
normal and remnant kidney rats. Background Hyperuricemia has been associated with renal …