The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …
Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors
P Huebbe, G Rimbach - Ageing research reviews, 2017 - Elsevier
Apolipoprotein E (APOE) is a member of the vertebrate protein family of exchangeable
apolipoproteins that is characterized by amphipathic α-helices encoded by multiple …
apolipoproteins that is characterized by amphipathic α-helices encoded by multiple …
Apolipoprotein E and viral infection: Risks and Mechanisms
Apolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and
cholesterol homeostasis. In addition to being a well-known genetic determinant of both …
cholesterol homeostasis. In addition to being a well-known genetic determinant of both …
The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
Approximately one-quarter of the variation in lifespan in developed countries can be
attributed to genetic factors. However, even large population based studies investigating …
attributed to genetic factors. However, even large population based studies investigating …
COVID-19 and Alzheimer's disease: How one crisis worsens the other
Alzheimer's disease (AD) has emerged as a key comorbidity of coronavirus disease 2019
(COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
(COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
COVID‐19 and the impact on Alzheimer's disease pathology
Abstract Coronavirus disease 2019 (COVID‐19) has rapidly escalated into a global
pandemic that primarily affects older and immunocompromised individuals due to …
pandemic that primarily affects older and immunocompromised individuals due to …
The ApoE locus and COVID-19: are we going where we have been?
CE Finch, AM Kulminski - The Journals of Gerontology: Series A, 2021 - academic.oup.com
Four decades ago in 1985, alleles of apolipoprotein E (ApoE) ε2/ε3/ε4 became famous for
explaining 16% of genetic variance in low-density lipoprotein cholesterol in the benchmark …
explaining 16% of genetic variance in low-density lipoprotein cholesterol in the benchmark …
The exposome in human evolution: from dust to diesel
BC Trumble, CE Finch - The Quarterly Review of Biology, 2019 - journals.uchicago.edu
Global exposures to air pollution and cigarette smoke are novel in human evolutionary
history and are associated with at least 12 million premature deaths per year. We investigate …
history and are associated with at least 12 million premature deaths per year. We investigate …
Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults
J Weiss, S Hossain, AI Maldonado, B Shen… - Scientific reports, 2021 - nature.com
We examined associations between cognition and mortality and how these relationships
vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle …
vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle …
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism
I Espinosa-Salinas, G Colmenarejo… - Scientific Reports, 2022 - nature.com
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public
health emergency. Increasing understanding about predisposing factors to infection and …
health emergency. Increasing understanding about predisposing factors to infection and …