The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early
repolarization syndrome (ERS), have captured the interest of the cardiology community over …

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation
of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric …

Objectives: The aim of this study was to provide the spectrum and prevalence of mutations in
the 12 Brugada syndrome (BrS)–susceptibility genes discovered to date in a single large …

Brugada syndrome is a heritable channelopathy characterized by a peculiar
electrocardiogram (ECG) pattern and increased risk of cardiac arrhythmias and sudden …

Background Atrial fibrillation (AF) is a common arrhythmia seen in clinical practice.
Occasionally, no common risk factors are present in patients with this arrhythmia. This …

A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia
syndromes, including the Brugada syndrome and early repolarization syndromes. Brugada …

Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome first described as a
new clinical entity in 1992. Electrocardiographically characterized by distinct coved type ST …

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting 1–2% of the general
population. A number of studies have demonstrated that AF, and in particular lone AF, has a …

Voltage-gated sodium channels are protein complexes comprised of one pore forming α
subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β …