Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …

Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during
the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines …

Hierarchic self-assembly underpins much of the form and function seen in synthetic or
biological soft materials. Lipids are paramount examples, building themselves in nature or …

The targeted delivery to specific locations while not causing damage to healthy tissues
efficiently remains a challenge in drug delivery systems. Through addressing this issue …

Diffusion of nanomedicines inside the extracellular matrix (ECM) has been identified as a
key factor to achieve homogeneous distribution and therefore therapeutic efficacy. Here, we …

The development of mRNA delivery systems utilizing lipid-based assemblies holds immense
potential for precise control of gene expression and targeted therapeutic interventions …

Background BF211, a derivative of bufalin (BF), shows significantly improved solubility and
potent antitumor efficiency compared to BF. Unfortunately, the unwanted toxicity such as …

One of the most important health concerns in society is the development of pathogen-
causing nosocomial infections. Since the first discovery of antibiotics, bacterial infections …

Abstract Lipid-based nanoparticles (LNPs), ranging from nanovesicles to non-lamellar
assemblies, have gained significant attention in recent years, as versatile carriers for …