Parkinson's disease

BR Bloem, MS Okun, C Klein - The Lancet, 2021 - thelancet.com
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

Monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: past, present, and future

YY Tan, P Jenner, SD Chen - Journal of Parkinson's Disease, 2022 - content.iospress.com
Abstract Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic
treatment of Parkinson's disease (PD). MAO-B inhibitor monotherapy has been shown to be …

Association of motor and nonmotor symptoms with health-related quality of life in a large online cohort of people with Parkinson disease

MA Bock, EG Brown, L Zhang, C Tanner - Neurology, 2022 - AAN Enterprises
Background and Objectives There is growing interest in health-related quality of life
(HRQOL) as a comprehensive view of the patient's well-being, guiding concept for the …

The role of α-synuclein in the regulation of serotonin system: physiological and pathological features

L Miquel-Rio, U Sarriés-Serrano, R Pavia-Collado… - Biomedicines, 2023 - mdpi.com
In patients affected by Parkinson's disease (PD), up to 50% of them experience cognitive
changes, and psychiatric disturbances, such as anxiety and depression, often precede the …

Predictors of clinically significant quality of life impairment in Parkinson's disease

D Santos García, T de Deus Fonticoba, C Cores… - npj Parkinson's …, 2021 - nature.com
Quality of life (QOL) plays an important role in independent living in Parkinson's disease
(PD) patients, being crucial to know what factors impact QoL throughout the course of the …

Cognitive impairment and dementia in young onset Parkinson's disease

D Santos-García, T de Deus Fonticoba… - Journal of …, 2023 - Springer
Background and objective Patients with young-onset Parkinson's disease (YOPD) have a
slower progression. Our aim was to analyze the change in cognitive function in YOPD …

If art were a drug: implications for Parkinson's disease

P Gros, BTM Spee, BR Bloem… - Journal of Parkinson's …, 2024 - journals.sagepub.com
Parkinson's disease (PD) is a chronic and complex neurodegenerative disorder.
Conventional pharmacological or surgical therapies alone are often insufficient at …

Safinamide improves non-motor symptoms burden in Parkinson's disease: an open-label prospective study

D Santos Garcia, C Labandeira Guerra, R Yanez Bana… - Brain Sciences, 2021 - mdpi.com
Some studies observed a benefit of Parkinson's disease (PD) patients after treatment with
safinamide in some non-motor symptoms (NMSs). The aim of this study was to analyze the …

Sexual dysfunction in Parkinson disease: a multicenter Italian cross-sectional study on a still overlooked problem

L Raciti, MC De Cola, P Ortelli, F Corallo… - The Journal of …, 2020 - academic.oup.com
Background Prevalence rates of sexual dysfunction (SD) in Parkinson's disease (PD) are
likely to be underestimated and their etiology is still unknown. More understanding of this …

Retinal degeneration: a window to understand the origin and progression of Parkinson's disease?

Y Zhang, X Zhang, Y Yue, T Tian - Frontiers in Neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, manifests
with motor and non-motor symptoms associated with two main pathological hallmarks …