The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …

Regeneration across tissues and organs exhibits significant variation throughout the body
and undergoes a progressive decline with age. To decode the relationships between aging …

Organ degeneration refers to the gradual decline in organ function and structure
deterioration that occurs during aging, which represents the greatest risk factor for various …

Musculoskeletal frailty—a common and debilitating condition linked to aging and chronic
diseases—presents a major public health issue. In vivo models have become a key tool for …

Skeletal muscle possesses remarkable regenerative capabilities, fully recovering within a
month following severe acute damage. Central to this process are muscle satellite cells …

Background Gut microbiota and their metabolites play a regulatory role in skeletal muscle
growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3 …

Background Sestrins have been implicated in regulating aging in various organs through
multiple pathways. However, their roles in ovarian aging remain unrevealed. Methods …

The skeletal muscle is an important organ for movement and metabolism in human body,
and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia …