TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
PH Alday, JS Doggett - Drug design, development and therapy, 2017 - Taylor & Francis
Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require …
Cryptosporidium is one of the most widespread protozoan parasites that infects domestic and wild animals and is considered the second major cause of diarrhea and death in …
Calcium signalling coordinates motility, cell invasion, and egress by apicomplexan parasites, yet the key mediators that transduce these signals remain largely unknown. One …
J Ajiboye, JE Teixeira, M Gasonoo, EB Mattice… - Nature …, 2024 - nature.com
Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in children and immunocompromised people. There is only one approved treatment that is …
H Sparks, G Nair, A Castellanos-Gonzalez… - … tropical medicine reports, 2015 - Springer
Cryptosporidiosis is increasingly recognized as an important global health concern. While initially reported in immunocompromised patients such as AIDS patients, cryptosporidiosis …
Apicomplexan parasites have complex life cycles, frequently split between different hosts and reliant on rapid responses as the parasites react to changing environmental conditions …
RE Hajj, L Tawk, S Itani, M Hamie, J Ezzeddine… - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a prevalent disease affecting a wide range of hosts including approximately one-third of the human population. It is caused by the sporozoan parasite …
A Diptyanusa, IP Sari - International Journal for Parasitology: Drugs and …, 2021 - Elsevier
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis …