A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

W Checkley, AC White, D Jaganath… - The Lancet Infectious …, 2015 - thelancet.com
Cryptosporidium spp are well recognised as causes of diarrhoeal disease during
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …

Malaria medicines: a glass half full?

TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

Drugs in development for toxoplasmosis: advances, challenges, and current status

PH Alday, JS Doggett - Drug design, development and therapy, 2017 - Taylor & Francis
Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …

Genomics and molecular epidemiology of Cryptosporidium species

A Khan, JS Shaik, ME Grigg - Acta Tropica, 2018 - Elsevier
Cryptosporidium is one of the most widespread protozoan parasites that infects domestic
and wild animals and is considered the second major cause of diarrhea and death in …

Distinct signalling pathways control Toxoplasma egress and host‐cell invasion

S Lourido, K Tang, LD Sibley - The EMBO journal, 2012 - embopress.org
Calcium signalling coordinates motility, cell invasion, and egress by apicomplexan
parasites, yet the key mediators that transduce these signals remain largely unknown. One …

Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

J Ajiboye, JE Teixeira, M Gasonoo, EB Mattice… - Nature …, 2024 - nature.com
Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in
children and immunocompromised people. There is only one approved treatment that is …

Treatment of Cryptosporidium: what we know, gaps, and the way forward

H Sparks, G Nair, A Castellanos-Gonzalez… - … tropical medicine reports, 2015 - Springer
Cryptosporidiosis is increasingly recognized as an important global health concern. While
initially reported in immunocompromised patients such as AIDS patients, cryptosporidiosis …

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp

S Lourido, SNJ Moreno - Cell calcium, 2015 - Elsevier
Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …

Toxoplasmosis: Current and emerging parasite druggable targets

RE Hajj, L Tawk, S Itani, M Hamie, J Ezzeddine… - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a prevalent disease affecting a wide range of hosts including
approximately one-third of the human population. It is caused by the sporozoan parasite …

[HTML][HTML] Treatment of human intestinal cryptosporidiosis: A review of published clinical trials

A Diptyanusa, IP Sari - International Journal for Parasitology: Drugs and …, 2021 - Elsevier
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In
immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis …