Mammalian kidney development has helped elucidate the general concepts of
mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and …

The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …

Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

Glomerular podocytes express proteins, such as nephrin, that constitute the slit diaphragm,
thereby contributing to the filtration process in the kidney. Glomerular development has been …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …

The transdifferentiation of epithelial cells toward a mesenchymal condition (EMT) is a
complex process that allows tumor cells to migrate to ectopic sites. Cadherins are not just …

During kidney development and in response to inductive signals, the metanephric
mesenchyme aggregates, becomes polarized, and generates much of the epithelia of the …

Abstract The Wilms' Tumour gene WT1 has important functions during development. Knock-
out mice were shown to have defects in the urogenital system and to die at embryonic day …