The tubulin code and its role in controlling microtubule properties and functions

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

The tubulin code in microtubule dynamics and information encoding

A Roll-Mecak - Developmental cell, 2020 - cell.com
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

The tubulin code, from molecules to health and disease

ED McKenna, SL Sarbanes… - Annual Review of …, 2023 - annualreviews.org
Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins

A Ramkumar, BY Jong… - Developmental …, 2018 - Wiley Online Library
Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Tubulin post-translational modifications and microtubule dynamics

D Wloga, E Joachimiak, H Fabczak - International journal of molecular …, 2017 - mdpi.com
Microtubules are hollow tube-like polymeric structures composed of α, β-tubulin
heterodimers. They play an important role in numerous cellular processes, including …

DYRK1A and cognition: A lifelong relationship

ML Arbones, A Thomazeau… - Pharmacology & …, 2019 - Elsevier
The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Tubulin post-translational modifications: the elusive roles of acetylation

B Carmona, HS Marinho, CL Matos, S Nolasco… - Biology, 2023 - mdpi.com
Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity

R Yang, KK Walder-Christensen… - Proceedings of the …, 2019 - National Acad Sciences
Giant ankyrin-B (ankB) is a neurospecific alternatively spliced variant of ANK2, a high-
confidence autism spectrum disorder (ASD) gene. We report that a mouse model for human …

Intrinsic and extrinsic factors affecting microtubule dynamics in normal and cancer cells

F Borys, E Joachimiak, H Krawczyk, H Fabczak - Molecules, 2020 - mdpi.com
Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

Tubulin post‐translational modifications control neuronal development and functions

MJ Moutin, C Bosc, L Peris… - Developmental …, 2021 - Wiley Online Library
Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are
involved in various aspects of neuron development, maintenance, and functions including …