Alzheimer's disease is a global public health problem and the most common form of
dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and …

Social isolation (SI) is a common phenomenon in the modern world, especially during the
coronavirus disease 2019 pandemic, and causes lasting cognitive impairments and mental …

The interaction mechanisms between bovine serum albumin (BSA) and quercetin
(Que)/myricetin (Myc) were explored by multi-spectroscopy and molecular dynamics …

The burden of Alzheimer's disease, the most prevalent neurodegenerative disease, is
increasing exponentially due to the increase in the elderly population worldwide. Synaptic …

Histidine behaviors play critical roles in folding and misfolding processes due to the
changes in net charge and the various N/N–H orientations on imidazole rings. However, the …

Prussian Blue (PB) modified carbon screen printed electrodes (SPE) were successfully
applied for detection of amyloid-β (Aβ) peptides of various lengths and amino acid …

Monitoring early-stage β-amyloid (Aβ) dimerization is a formidable challenge for
understanding neurological diseases. We compared β-sheet formation and histidine site …

Controlling protein misfolding and accumulation in neurodegeneration is a challenge in
chemical neuroscience. The application of appropriate electric fields (EFs) can be a …

Hundreds of millions of people around the world have been affected by Type 2 diabetes
(T2D) which is a metabolic disorder. Clinical research has revealed T2D as a possible risk …

Abstract Characterization of the conformational alterations involved in monomer misfolding
is essential for elucidating the molecular basis of the initial stage of protein accumulation …