Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries
A Montinaro, H Walczak - Cell Death & Differentiation, 2023 - nature.com
Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
S Von Karstedt, A Montinaro, H Walczak - Nature Reviews Cancer, 2017 - nature.com
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
Getting TRAIL back on track for cancer therapy
JV Lemke, S von Karstedt, J Zinngrebe… - Cell Death & …, 2014 - nature.com
Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
Onto better TRAILs for cancer treatment
D de Miguel, J Lemke, A Anel, H Walczak… - Cell Death & …, 2016 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …
Death receptor–ligand systems in cancer, cell death, and inflammation
H Walczak - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The discovery of tumor necrosis factor (TNF) marked the beginning of one of the most
fascinating journeys in modern biomedical research. For the moment, this journey has …
fascinating journeys in modern biomedical research. For the moment, this journey has …
The multifaceted role of TRAIL signaling in cancer and immunity
L Cardoso Alves, N Corazza, O Micheau… - The FEBS …, 2021 - Wiley Online Library
Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …
Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis
S von Karstedt, A Conti, M Nobis, A Montinaro… - Cancer cell, 2015 - cell.com
Many cancers harbor oncogenic mutations of KRAS. Effectors mediating cancer
progression, invasion, and metastasis in KRAS-mutated cancers are only incompletely …
progression, invasion, and metastasis in KRAS-mutated cancers are only incompletely …
Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family
K Azijli, B Weyhenmeyer, GJ Peters… - Cell Death & …, 2013 - nature.com
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapy is currently
evaluated in clinical studies as a tumor cell selective pro-apoptotic approach. However …
evaluated in clinical studies as a tumor cell selective pro-apoptotic approach. However …
Death receptors as targets in cancer
Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …