Genetic-by-age interaction analyses on complex traits in UK Biobank and their potential to identify effects on longitudinal trait change
TW Winkler, S Wiegrebe, JM Herold, KJ Stark… - Genome Biology, 2024 - Springer
Background Genome-wide association studies (GWAS) have identified thousands of loci for
disease-related human traits in cross-sectional data. However, the impact of age on genetic …
disease-related human traits in cross-sectional data. However, the impact of age on genetic …
Improved two‐step testing of genome‐wide gene–environment interactions
ES Kawaguchi, AE Kim, JP Lewinger… - Genetic …, 2023 - Wiley Online Library
Two‐step tests for gene–environment (G× EG*E) interactions exploit marginal single‐
nucleotide polymorphism (SNP) effects to improve the power of a genome‐wide interaction …
nucleotide polymorphism (SNP) effects to improve the power of a genome‐wide interaction …
Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
WJ Gauderman, Y Fu, B Quem, E Kawaguchi, Y Wang… - bioRxiv, 2024 - biorxiv.org
A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic
variants. For complex human traits there is interest in determining whether the PRS modifies …
variants. For complex human traits there is interest in determining whether the PRS modifies …
Two-Stage Testing in a high dimensional setting
In a high dimensional regression setting in which the number of variables ($ p $) is much
larger than the sample size ($ n $), the number of possible two-way interactions between the …
larger than the sample size ($ n $), the number of possible two-way interactions between the …
[HTML][HTML] A note on p-value multiple-testing adjustment for two-step genome-wide gene-environment interactions scans
JP Lewinger, ES Kawaguchi, WJ Gauderman - medRxiv, 2023 - ncbi.nlm.nih.gov
Two-step testing is the state-of-the art approach for performing genome-wide interaction
scans (GWIS). It is computationally efficient and yields higher power than standard single …
scans (GWIS). It is computationally efficient and yields higher power than standard single …
Validity and Power of the Case-Only Approach in Prospective Cohort and Case-Cohort Studies with Time-to-Event Endpoints
S Freitag-Wolf, OM Akinloye, A Dempfle - 2024 - researchsquare.com
Background For genetic epidemiological studies with binary outcomes, the case-only (CO)
approach has been shown to be powerful for examining statistical interactions, in particular …
approach has been shown to be powerful for examining statistical interactions, in particular …
Validity and power of the case-only approach in prospective cohort and case-cohort studies with time-to-event endpoints: a simulation study
S Freitag-Wolf, M Akinloye, A Dempfle - 2024 - researchsquare.com
Objective The powerful case-only (CO) approach has been extended for examining
statistical interactions for time-to-event outcomes in the context of randomized clinical trials …
statistical interactions for time-to-event outcomes in the context of randomized clinical trials …
A novel significance-based approach to two-stage hypothesis testing for discovery of gene-environment interactions
ES Kawaguchi, AE Kim, JP Lewinger, WJ Gauderman - bioRxiv, 2022 - biorxiv.org
Two-step tests for gene-environment (G× E) interactions, exploit marginal SNP effects to
improve the power of genome-wide interaction scan (GWIS). They combine a screening step …
improve the power of genome-wide interaction scan (GWIS). They combine a screening step …