Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …

Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …

Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal
dominant Alzheimer's disease,,. Cleavage of APP by unidentified proteases, referred to as β …

The Alzheimer's disease β-amyloid peptide (Aβ) is produced by excision from the type 1
integral membrane glycoprotein amyloid precursor protein (APP) by the sequential actions …

For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

▪ Abstract Intensive studies of three proteins—Presenilin, Notch, and the amyloid precursor
protein (APP)—have led to the recognition of a direct intersection between early …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …