Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions
and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and-extrinsic …

Glioma stem cells (GSCs) decrease T cells cognition and evade systemic
immunosurveillance via downregulations or defects of major histocompatibility complex …

In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …

Recent revival of interest in the role of immune surveillance in the pathogenesis and control
of malignant diseases has focused attention on escape mechanisms used by tumor cells to …

Histone deacetylase inhibitors (HDACi), including trichostatin A (TSA) and valproic acid, can
alter the acetylation of histones in chromatin and enhance gene transcription. Previously we …

Histone deacetylase inhibitors (HDACi) have been hailed as a powerful new class of
anticancer drugs. The HDACi, trichostatin A (TSA), is thought to interfere with epigenetic …

The anti-tumor immune response has been shown to be of great prognostic importance in
colorectal cancer (CRC) and so has the tumors ability for immune evasion. Our aim of this …

In this chapter I describe Tumour Immune Escape mechanisms associated with MHC/HLA
class I loss in human and experimental tumours. Different altered HLA class-I phenotypes …

The immunosuppressive environment of advanced tumors is a primary obstacle to the
efficacy of immunostimulatory and vaccine approaches. Here, we report an approach to arm …