Accumulating evidence suggests that the human intestinal microbiota contributes to the
aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific …

Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The
incidence and mortality rates of CRC have been increasing in China, possibly due to …

Intestinal microbiota have emerged as an important factor in colorectal cancer (CRC)
initiation and progression. The currently prominent view on bacterial tumorigenesis is that …

Accumulating recent evidence indicates that the human microbiome plays essential roles in
pathophysiological states, including cancer. The tumor microbiome, an emerging concept …

Humans, throughout the life cycle, from birth to death, are accompanied by the presence of
gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of …

Abstract Purpose of Review In this review, we discuss how environmental exposures
predominate the etiology of colorectal cancer (CRC). With CRC being a personalized …

Fluorouracil (5-FU) is an antimetabolite drug widely used for the treatment of skin cancer.
Despite its proven efficacy in treating malignancies, its systemic administration is limited due …

USP2a is a deubiquitinase responsible for stabilization of cyclin D1, a crucial regulator of
cell-cycle progression and a proto-oncoprotein overexpressed in numerous cancer types …

It is well-established that there are trillions of gut microbiota (GM) in the human gut. GM and
its metabolites can reportedly cause cancer by causing abnormal immune responses. With …

The advantages of a treatment modality that combines two or more therapeutic agents in
cancer therapy encourages the study of hybrid functional compounds for pharmacological …