The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Osteoclasts are the exclusive bone-resorbing cells, playing a central role in bone
metabolism, as well as the bone damage that occurs under pathological conditions,. In …

Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the
regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative …

General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …

Abstract General Control Non-repressed 5 protein (GCN5), encoded by the mammalian
gene Kat2a, is the first histone acetyltransferase discovered to link histone acetylation to …

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of
obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and …

When it comes to the epigenome, there is a fine line between clarity and confusion—walk
that line and you will discover another fascinating level of transcription control. With the …

GCN5, conserved from yeast to humans, and the vertebrate specific PCAF, are lysine
acetyltransferase enzymes found in large protein complexes. Both enzymes have well …

Transcription factors directly regulate gene expression by recognizing and binding to
specific DNA sequences, involving the dynamic alterations of chromatin structure and the …