In bacteria, more than half of the genes in the genome are organized in operons. In contrast,
in eukaryotes, functionally related genes are usually dispersed across the genome. There …

Covering: up to June 2006We review the literature on the enzymes, genes, and whole gene
clusters underlying natural product biosyntheses and their regulation in filamentous fungi …

Fungi are prolific producers of natural products, compounds which have had a large societal
impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over …

Fusarium (Hypocreales, Nectriaceae) is one of the most economically important and
systematically challenging groups of mycotoxigenic phytopathogens and emergent human …

In the postgenomic era it has become increasingly apparent that the vast number of
predicted biosynthesis genes of microorganisms is not reflected by the metabolic profile …

As the 20th century ended, Fusarium mycotoxicology entered the age of genomics. With
complete genomes of Fusarium graminearum and F. verticillioides and several Fusarium …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Highly reducing iterative polyketide synthases are large, multifunctional enzymes that make
important metabolites in fungi, such as lovastatin, a cholesterol-lowering drug from …

The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

Significant developments in the isolation of tetramic acids and tetronic acids, in the
elucidation of their biosyntheses and their biological activities and in laboratory syntheses …