Summary In sub-Saharan Africa (SSA), urgent action is needed to curb a growing crisis in
cancer incidence and mortality. Without rapid interventions, data estimates show a major …

Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Abstract Context Men of African ancestry have demonstrated markedly higher rates of
prostate cancer mortality than men of other races and ethnicities around the world. In fact …

Background Accurate assessment of health disparities requires unbiased knowledge of
genetic risks in different populations. Unfortunately, most genome-wide association studies …

The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

Despite recent rapid advances in medical knowledge that have improved survival,
conventional medical science's understanding of human health and disease relies heavily …

Cancer health disparities remain stubbornly entrenched in the US health care system. The
Affordable Care Act was legislation to target these disparities in health outcomes. Expanded …

Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Background Genome-wide association studies do not always replicate well across
populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher …

Self-identified race/ethnicity is a correlate of both genetic ancestry and socioeconomic
factors, both of which may contribute to racial disparities in mortality. Investigators often hold …