More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure

JA Fonseca, AC King, A Chahroudi - Current HIV/AIDS Reports, 2024 - Springer
Abstract Purpose of Review An HIV cure that eliminates the viral reservoir or provides viral
control without antiretroviral therapy (ART) is an urgent need in children as they face unique …

Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation

KM Bricker, V Obregon-Perko, F Uddin… - PLoS …, 2020 - journals.plos.org
Globally, 1.8 million children are living with HIV-1. While antiretroviral therapy (ART) has
improved disease outcomes, it does not eliminate the latent HIV-1 reservoir. Interventions to …

Advances in simian--human immunodeficiency viruses for nonhuman primate studies of HIV prevention and cure

AM Bauer, KJ Bar - Current Opinion in HIV and AIDS, 2020 - journals.lww.com
Advances in simian--human immunodeficiency viruses for nonhu... : Current Opinion in HIV and
AIDS Advances in simian--human immunodeficiency viruses for nonhuman primate studies of …

Investigation of Immune Interventions in SIV-Infected, ART-Treated Infant Rhesus Macaques

KM Bricker - 2021 - search.proquest.com
The latent viral reservoir is composed of a small subset of infected CD4+ T cells that persist
during antiretroviral therapy (ART) and constitute the major barrier to HIV-1 cure. Strategies …

Identical HIV-1 Proviruses Originate from Cell Proliferation or Infection with a Common Viral Ancestor

A Niyongabo - 2020 - search.proquest.com
Understanding the mechanisms for HIV-1 persistence during antiretroviral therapy (ART) is
crucial for developing curative strategies. Due to the high intra-patient genetic diversity of …