Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

The gut microbiota is a major factor contributing to the regulation of energy homeostasis and
has been linked to both excessive body weight and accumulation of fat mass (ie, overweight …

Disruption of mitochondrial function and protein homeostasis plays a central role in aging.
However, how these processes interact and what governs their failure in aging remain …

Biologically active sphingolipids are closely related to the growth, differentiation, aging, and
apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites …

Automated detection of specific cells in three-dimensional datasets such as whole-brain light-
sheet image stacks is challenging. Here, we present DELiVR, a virtual reality-trained deep …

Background Cancer‐associated cachexia (CAC) is a wasting syndrome drastically reducing
efficacy of chemotherapy and life expectancy of patients. CAC affects up to 80% of cancer …

Cancer cachexia is a severe systemic wasting disease that negatively affects quality of life
and survival in patients with cancer. To date, treating cancer cachexia is still a major unmet …

Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant
cell growth and both processes represent targets for anticancer therapy. It is shown here that …

Cancer cachexia is a complex metabolic disorder marked by unintentional body weight loss
or 'wasting'of body mass, driven by multiple aetiological factors operating at various levels. It …

Cancer cachexia can be defined as a complex metabolic syndrome characterized by weight
loss, anorexia, and emaciation due to the wasting of adipose tissue and skeletal muscle. In …