Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic
functions. In a previous review, we identified 3370 references reporting on 178 different …

A biomarker is a molecule that can be measured in a biological sample in an objective,
systematic, and precise way, whose levels indicate whether a process is normal or …

Background: It was studied if early suPAR-guided anakinra treatment can prevent severe
respiratory failure (SRF) of COVID-19. Methods: A total of 130 patients with suPAR≥ 6 ng/ml …

As of April 1, 2020, 885,689 cases of infections by the novel coronavirus SARS-CoV-2
(COVID-19) have been recorded worldwide; 44,217 of them have died (https://www …

Background A subanalysis of a randomized clinical trial indicated sepsis survival benefit
from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like …

The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐
inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects …

Objectives Sepsis-3 definitions generated controversies regarding their general
applicability. The Sepsis-3 Task Force outlined the need for validation with emphasis on the …

Fast and appropriate therapy is the cornerstone in the therapy of sepsis. However, the
discrimination of sepsis from non-infectious causes of inflammation may be difficult …

Introduction Platelet indices, including mean platelet volume (MPV), are readily available
blood tests, although their prognostic value in patients with septic shock has not been fully …

Purpose The soluble form of the urokinase-type plasminogen activator receptor (suPAR)
and proadrenomedullin (proADM) are two new and promising sepsis biomarkers. We …