Due to the ability to regulate target metabolic pathways globally and dynamically, metabolic
regulation systems composed of transcription factors have been widely used in metabolic …

Recognition of the DNA minor groove by pyrrole-imidazole polyamides - ScienceDirect Skip
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Determining the sequence-recognition properties of DNA-binding proteins and small
molecules remains a major challenge. To address this need, we have developed a high …

Recent advances in the design, selection, and engineering of DNA binding proteins have
led to the emerging field of designer transcription factors (TFs). Modular DNA-binding …

Mapping and sequencing the genetic blueprint in human, mice, yeast and other model
organisms has created challenges and opportunities for chemistry, biology and human …

The aberrant epigenetic silencing of tumor suppressor genes (TSGs) plays a major role
during carcinogenesis and regaining these dormant functions by engineering of sequence …

Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only
publication that provides a comprehensive compilation of plant transcription factor families …

SynTEF1, a prototype synthetic genome reader/regulator (SynGR), was designed to target
GAA triplet repeats and restore the expression of frataxin (FXN) in Friedreich's ataxia …

In order to explore the apoptotic and anti-tumor activities of metallo-salens, we synthesized
several Mn (III)-salen derivatives (compds. 1–9) and analyzed their effects on cultured …

Despite their versatility and power in controlling gene regulation in nature, nuclear hormone
receptors (NHRs) have largely eluded utility in heterologous gene regulation applications …