The emergence of genetic engineering at the beginning of the 1970′ s opened the era of
biomedical technologies, which aims to improve human health using genetic manipulation …

Inflammatory bowel disease (IBD), which comprises two main types, namely, Crohn's
disease and ulcerative colitis, affects approximately 3.6 million people in the USA and …

The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase,
LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP) …

Adenoviruses are used extensively as gene transfer agents, both experimentally and
clinically. However, targeting of liver cells by adenoviruses compromises their potential …

A major obstacle limiting gene therapy for diseases of the heart and skeletal muscles is an
inability to deliver genes systemically to muscles of an adult organism. Systemic gene …

Signal transduction pathways control cellular responses to stimuli, but it is unclear how
molecular information is processed as a network. We constructed a systems model of 7980 …

To evaluate the contribution of the innate immune component of host defense in clearing the
genome of adenovirus (Ad) vectors following in vivo administration, the Ad vectors AdCMV …

The apolipoprotein apoC-III plays an important role in plasma triglyceride metabolism. It is
predominantly produced in liver, and its hepatic expression is inhibited by insulin. To …

To expand the utility of recombinant adenovirus vectors for gene therapy applications,
methods to alter native viral tropism to achieve cell-specific transduction would be beneficial …

Natural and genetically modified oncolytic viruses have been systematically tested as
anticancer therapeutics. Among this group, conditionally replicative adenoviruses have …