Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …

Simple Summary Carriers of Lynch syndrome (LS) have an increased risk for several types
of tumour, in particular bowel and uterine cancers. LS is caused by inheritance of a faulty …

Background Lynch-like syndrome (LLS) tumors have similar clinicopathological features to
Lynch syndrome (LS) tumors but have no identifiable pathogenic germline mismatch repair …

Pathogenic germline variants in the DNA polymerase genes POLE and POLD1 cause
polymerase proofreading-associated polyposis, a dominantly inherited disorder with …

Endometrial cancer is one of the most common cancers among women. The International
Collaboration on Cancer Reporting (ICCR) developed a standardized endometrial cancer …

Background Immune checkpoint inhibitor (ICI) therapy has proven to be a promising
treatment for colorectal cancer (CRC). We aim to investigate the relationship between DNA …

Lynch syndrome (LS) is the main hereditary colorectal cancer syndrome. There have been
few reports regarding the clinical and molecular characteristics of LS patients in Latin …

Simple Summary This study addresses the global healthcare challenge of cancer by
investigating hereditary cancer syndromes (HCS) and their genetic underpinnings. Using a …

Thyroid carcinoma (TC) can be classified as medullary (MTC) and non-medullary (NMTC).
While most TCs are sporadic, familial forms of MTC and NMTC also exist (less than 1% and …

Epigenetic clocks are DNA methylation-based chronological age prediction models that are
commonly employed to study age-related biology. The difference between the predicted and …