Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …

Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie …

Childhood cancer survival rates are now nearly 80% in more developed European countries
because of improved therapies and better supportive care. Platinum chemotherapy drugs …

Tinnitus: A Multidisciplinary Approach provides a broad account of tinnitus and hyperacusis,
detailing the latest research and developments in clinical management, incorporating …

Cisplatin is a highly effective treatment for malignant cancers and has become a cornerstone
in chemotherapeutic regimens. Unfortunately, its use in the clinic is often coupled with a high …

Introduction Cisplatin is a very effective chemotherapeutic agent against a variety of solid
tumors. Unfortunately, cisplatin causes permanent sensorineural hearing loss in at least two …

Cisplatin derivatives are used as the mainline treatment of ovarian cancer, despite their
severe side effects and development of resistance. We developed a novel combination …

Objective: This review will summarise the current state of development of pharmaceutical
interventions (prevention or treatment) for medication-induced ototoxicity. Design: Currently …

This study presents a novel in vitro model of electrode insertion trauma‐induced hair cell
(HC) damage and loss and its application for testing the efficacy of otoprotective drugs. In …