The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …

The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the
pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of …

Purpose: To elucidate molecular pathways contributing to metastatic cancer progression
and poor clinical outcome in serous ovarian cancer. Experimental Design: Poor survival …

Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after
injury. The function of kidney pericytes as microvascular cells and how these cells detach …

Tissue inhibitor of metalloproteinase-3 (TIMP-3), a secreted glycoprotein, plays an important
role in carcinogenesis. It can bind to many proteinases to suppress their activity and thus …

Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were
originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase …

Lung cancer is the leading cause of cancer-related mortality, which histologically is
classified into small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) …

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of
malignant tumours typically caused by alcohol and tobacco consumption, although an …

ADAM17, also known as tumor necrosis factor-α converting enzyme (TACE), is involved in
proteolytic ectodomain shedding of cell surface molecules and cytokines. Although aberrant …

Circulating tumor cells (CTCs) have emerged as a reliable source of tumor cells, and their
concentration has prognostic implications. CTC capture offers real-time access to cancer …