Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC).
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures
may play a critical role in early programming for childhood and adult illness. Maternal …

The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …

Summary Gfi-1 and Gfi-1b are homologous transcriptional repressors involved in diverse
developmental contexts, including hematopoiesis and oncogenesis. Transcriptional …

Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …

Mammalian euchromatic gene silencing results from the combined repressive effects of
histone and DNA methyltransferases. Little is known of the mechanism by which these …

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in
which no mutation of pathogenic gene (s) has been identified. Instead, the disease is, in …

Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of
proteins and organelles. Although the cytoplasmic machinery that orchestrates autophagy …