Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

R Margiana, A Markov, AO Zekiy, MU Hamza… - Stem Cell Research & …, 2022 - Springer
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …

Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee

S Jang, K Lee, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …

Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice

C Li, H Zhao, L Cheng, B Wang - Cell & Bioscience, 2021 - Springer
Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

Mesenchymal stem cells for cartilage regeneration

H Le, W Xu, X Zhuang, F Chang… - Journal of Tissue …, 2020 - journals.sagepub.com
Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune
diseases. Owing to the avascular structure and low metabolic activities of chondrocytes …

Strategies for articular cartilage repair and regeneration

Y Liu, KM Shah, J Luo - Frontiers in Bioengineering and …, 2021 - frontiersin.org
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects
in articular cartilage can induce debilitating degenerative joint diseases such as …

Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis

XN Xiang, SY Zhu, HC He, X Yu, Y Xu… - Stem cell research & …, 2022 - Springer
Osteoarthritis, as a degenerative disease, is a common problem and results in high
socioeconomic costs and rates of disability. The most commonly affected joint is the knee …

Exosomes: roles and therapeutic potential in osteoarthritis

Z Ni, S Zhou, S Li, L Kuang, H Chen, X Luo, J Ouyang… - Bone research, 2020 - nature.com
Exosomes participate in many physiological and pathological processes by regulating cell–
cell communication, which are involved in numerous diseases, including osteoarthritis (OA) …