Ketamine and serotonergic psychedelics: an update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment
The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …
understand its underlying mechanisms of action and to identify other novel compounds that …
Synergistic psychedelic-NMDAR modulator treatment for neuropsychiatric disorders
U Heresco-Levy, B Lerer - Molecular Psychiatry, 2024 - nature.com
Modern research data suggest a therapeutic role for serotonergic psychedelics in
depression and other neuropsychiatric disorders, although psychotomimetic effects may limit …
depression and other neuropsychiatric disorders, although psychotomimetic effects may limit …
Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination
VK Miller, K Broadie - PLoS biology, 2024 - journals.plos.org
The optimization of brain circuit connectivity based on initial environmental input occurs
during critical periods characterized by sensory experience-dependent, temporally …
during critical periods characterized by sensory experience-dependent, temporally …
[HTML][HTML] Maturation of GABAergic Synaptic Transmission From Neocortical Parvalbumin Interneurons Involves N-methyl-D-aspartate Receptor Recruitment of Cav2. 1 …
N-methyl-D-aspartate receptor (NMDAR) hypofunction during brain development is likely to
contribute to the manifestation of schizophrenia (SCZ) in young adulthood. The cellular …
contribute to the manifestation of schizophrenia (SCZ) in young adulthood. The cellular …
A comprehensive evaluation of adverse childhood experiences, social–emotional impairments, and neurodevelopmental disorders in cannabis-use disorder …
G Trovini, E Amici, P Bauco, M Matrone… - European …, 2023 - cambridge.org
BackgroundAdverse childhood experiences (ACEs), social–emotional impairments (SEIs),
and neurodevelopmental disorders (NDs) are frequent in psychiatric disorders, including …
and neurodevelopmental disorders (NDs) are frequent in psychiatric disorders, including …
Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them–A scoping review …
L Miranda - Brain Research, 2024 - Elsevier
Psychedelic drugs that activate the 5HT2A receptor have long been the target of extensive
clinical research, particularly in models of psychiatric illness. The aim of this literature review …
clinical research, particularly in models of psychiatric illness. The aim of this literature review …
[HTML][HTML] Cognitive dysfunction in schizophrenia patients caused by down-regulation of γ-aminobutyric acid receptor subunits
X Chen, YN Zhou, XZ Lu, RJ Li, YF Xiong… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND The expression pattern of gamma aminobutyric acid (GABA) receptor
subunits are commonly altered in patients with schizophrenia, which may lead to nerve …
subunits are commonly altered in patients with schizophrenia, which may lead to nerve …
A computational account of the development and evolution of psychotic symptoms
The mechanisms of psychotic symptoms like hallucinations and delusions are often
investigated in fully-formed illness, well after symptoms emerge. These investigations have …
investigated in fully-formed illness, well after symptoms emerge. These investigations have …
Consecuencias de la hiperprolactinemia iatrogénica asociada a antipsicóticos en la enfermedad mental grave
JM Acosta Rodríguez - 2023 - gredos.usal.es
[ES] Antecedentes: La seguridad clínica es un aspecto esencial en el desarrollo y uso
terapéutico de medicamentos. La efectividad y seguridad farmacológica son la garantía de …
terapéutico de medicamentos. La efectividad y seguridad farmacológica son la garantía de …
Maturation of GABAergic Synaptic Transmission in Immature Neocortical Fast-Spiking Interneurons Involves NMDA Receptor Recruitment of Cav2. 1 Channels
NMDA receptor (NMDAR) hypofunction, in particular during brain development, is likely to
contribute to the manifestation of schizophrenia (SCZ) in young adulthood. The cellular …
contribute to the manifestation of schizophrenia (SCZ) in young adulthood. The cellular …