[HTML][HTML] Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal

M Tao, T Ao, X Mao, X Yan, R Javed, W Hou, Y Wang… - Bioactive materials, 2021 - Elsevier
Sterilization is the process of killing all microorganisms, while disinfection is the process of
killing or removing all kinds of pathogenic microorganisms except bacterial spores …

Heralding a new paradigm in 3D tumor modeling

ELS Fong, DA Harrington, MC Farach-Carson, H Yu - Biomaterials, 2016 - Elsevier
Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

Perfusion decellularization of whole organs

JP Guyette, SE Gilpin, JM Charest, LF Tapias, X Ren… - Nature protocols, 2014 - nature.com
The native extracellular matrix (ECM) outlines the architecture of organs and tissues. It
provides a unique niche of composition and form, which serves as a foundational scaffold …

Cancer-associated fibroblasts induce a collagen cross-link switch in tumor stroma

D Pankova, Y Chen, M Terajima… - Molecular Cancer …, 2016 - AACR
Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell
invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To …

Decellularization and recellularization technologies in tissue engineering

RH Fu, YC Wang, SP Liu, TR Shih, HL Lin… - Cell …, 2014 - journals.sagepub.com
Decellularization is the process by which cells are discharged from tissues/organs, but all of
the essential cues for cell preservation and homeostasis are retained in a three-dimensional …

Engineering the pre-metastatic niche

BA Aguado, GG Bushnell, SS Rao, JS Jeruss… - Nature biomedical …, 2017 - nature.com
The pre-metastatic niche—the accumulation of aberrant immune cells and extracellular-
matrix proteins in target organs—primes the initially healthy organ microenvironment and …

Decellularized tissues as platforms for in vitro modeling of healthy and diseased tissues

MW McCrary, D Bousalis, S Mobini, YH Song… - Acta biomaterialia, 2020 - Elsevier
Biomedical engineers are at the forefront of developing novel treatments to improve human
health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …

Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18

ML Pinto, E Rios, AC Silva, SC Neves, HR Caires… - Biomaterials, 2017 - Elsevier
Macrophages are frequently identified in solid tumors, playing important roles in cancer
progression. Their remarkable plasticity makes them very sensitive to environmental factors …

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization

G Mazza, W Al-Akkad, A Telese, L Longato, L Urbani… - Scientific Reports, 2017 - nature.com
The development of human liver scaffolds retaining their 3-dimensional structure and extra-
cellular matrix (ECM) composition is essential for the advancement of liver tissue …

Decellularized extracellular matrix for cancer research

T Hoshiba - Materials, 2019 - mdpi.com
Genetic mutation and alterations of intracellular signaling have been focused on to
understand the mechanisms of oncogenesis and cancer progression. Currently, it is pointed …