Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving from the traditional two-dimensional culture system to three-dimensional (3D) culture …
The native extracellular matrix (ECM) outlines the architecture of organs and tissues. It provides a unique niche of composition and form, which serves as a foundational scaffold …
D Pankova, Y Chen, M Terajima… - Molecular Cancer …, 2016 - AACR
Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To …
Decellularization is the process by which cells are discharged from tissues/organs, but all of the essential cues for cell preservation and homeostasis are retained in a three-dimensional …
The pre-metastatic niche—the accumulation of aberrant immune cells and extracellular- matrix proteins in target organs—primes the initially healthy organ microenvironment and …
MW McCrary, D Bousalis, S Mobini, YH Song… - Acta biomaterialia, 2020 - Elsevier
Biomedical engineers are at the forefront of developing novel treatments to improve human health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …
Macrophages are frequently identified in solid tumors, playing important roles in cancer progression. Their remarkable plasticity makes them very sensitive to environmental factors …
The development of human liver scaffolds retaining their 3-dimensional structure and extra- cellular matrix (ECM) composition is essential for the advancement of liver tissue …
Genetic mutation and alterations of intracellular signaling have been focused on to understand the mechanisms of oncogenesis and cancer progression. Currently, it is pointed …