The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

The concentration of intracellular and extracellular potassium is tightly regulated due to the
action of various ion transporters, channels, and pumps, which reside primarily in the kidney …

The urinary potassium (K+) excretion machinery is upregulated with increasing dietary K+,
but the role of accompanying dietary anions remains inadequately characterized. Poorly …

Chronic infusion of subpressor level of angiotensin II (ANG II) increases the abundance of
Na+ transporters along the distal nephron, balanced by suppression of Na+ transporters …

A primary function of intercalated cells in the distal tubule of the kidney is to maintain pH
homeostasis. For example, type B intercalated cells secrete bicarbonate largely through the …

Background: Losing or donating a kidney is associated with risks of developing
hypertension and albuminuria. Few studies address mechanisms or interventions. We …

Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic,
bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was …

Both KCC3b and KCC3a seem to be needed for maintaining cell volume during enhanced
inward cotransport of Na-glucose in proximal tubule and Na-HCO 3 in intercalated cells. In …

Abstract The renal Na-K-2Cl and Na-Cl cotransporters are the major salt reabsorption
pathways in the thick ascending limb of Henle's loop and the distal convoluted tubule …

The maintenance of plasma pH is critical for life in all organisms. The kidney plays a critical
role in acid–base regulation in vertebrates by controlling the plasma concentration of …