Organic Bioelectronics for In Vitro Systems

C Pitsalidis, AM Pappa, AJ Boys, Y Fu… - Chemical …, 2021 - ACS Publications
Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Autism genes converge on asynchronous development of shared neuron classes

B Paulsen, S Velasco, AJ Kedaigle, M Pigoni… - Nature, 2022 - nature.com
Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …

[HTML][HTML] Cell types of the human retina and its organoids at single-cell resolution

CS Cowan, M Renner, M De Gennaro, B Gross-Scherf… - Cell, 2020 - cell.com
Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

H Shin, S Jeong, JH Lee, W Sun, N Choi… - Nature communications, 2021 - nature.com
Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …

Neurohybrid memristive CMOS-integrated systems for biosensors and neuroprosthetics

A Mikhaylov, A Pimashkin, Y Pigareva… - Frontiers in …, 2020 - frontiersin.org
Here we provide a perspective concept of neurohybrid memristive chip based on the
combination of living neural networks cultivated in microfluidic/microelectrode system, metal …

SpikeInterface, a unified framework for spike sorting

AP Buccino, CL Hurwitz, S Garcia, J Magland… - Elife, 2020 - elifesciences.org
Much development has been directed toward improving the performance and automation of
spike sorting. This continuous development, while essential, has contributed to an over …

[HTML][HTML] Progress in multicellular human cardiac organoids for clinical applications

H Kim, RD Kamm, G Vunjak-Novakovic, JC Wu - Cell Stem Cell, 2022 - cell.com
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …

The need to approximate the use-case in clinical machine learning

S Saeb, L Lonini, A Jayaraman, DC Mohr… - …, 2017 - academic.oup.com
The availability of smartphone and wearable sensor technology is leading to a rapid
accumulation of human subject data, and machine learning is emerging as a technique to …

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

Y Shen, FS Ruggeri, D Vigolo, A Kamada… - Nature …, 2020 - nature.com
Membrane-less organelles resulting from liquid–liquid phase separation of biopolymers into
intracellular condensates control essential biological functions, including messenger RNA …