Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

The neurotransmitter dopamine has central roles in mood, appetite, arousal and movement.
Despite its importance in brain physiology and function, and as a target for illicit and …

Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …

There has been steadily growing interest in the participation of metal ions (especially, zinc,
copper, and iron) in neurobiological processes, such as the regulation of synaptic …

As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets β-
amyloid (Aß) reactions with synaptic Zn and Cu yet promotes metal uptake. Here we …

Alzheimer's disease is the most common form of dementia in the elderly, and it is
characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral …

Our understanding of the roles played by zinc in the physiological and pathological
functioning of the brain is rapidly expanding. The increased availability of genetically …

Zinc transporter-3 (ZnT3) protein controls synaptic vesicular Zn2+ levels, which is predicted
to regulate normal cognitive function. Surprisingly, previous studies found that 6-to 10-week …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …