Spirocyclic molecules are widely recognized for their complex three‐dimensional features
and structural rigidity. Among this class of molecules, the spiro‐lactams subclass stands out …

Exploiting the reversibility of chemical processes is a long-standing tactic of organic
chemists, and permeates most areas of the discipline. The notion that oxidative addition of …

Spiro-γ-lactams (spiropyrrolidin-2-ones) are a class of spirocyclic compounds that are
present in a wide range of synthetic bioactive and naturally occurring molecules. The …

Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the
structure of many pharmaceutically active molecules. They can be often synthesized by …

A general strategy for the design of asymmetric cascade reactions using readily available
halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic …

β-Lactam compounds play a key role in medicinal chemistry, specifically as the most
important class of antibiotics. Here, we report a novel one-step approach for the synthesis of …

The unprecedented Pd (II)-catalyzed cascade annulation of o-aminobenzoic acids with CO,
amines, and aldehydes has been developed. This protocol provides an efficient and concise …

The direct palladium-catalyzed selective carbonylative coupling of less reactive aryl
chlorides (including electron-rich,-neutral and-deficient ones) with primary and secondary …

Due to the emerging resistance against classical β‐lactam‐based antibiotics, a growing
number of bacterial infections has become harder to treat. This alarming tendency …

We herein report a palladium-catalyzed carbonylative cyclization reaction of ortho-
bromoarylimines that allows for the chemodivergent synthesis of functionalized …